Blood pressure, heart rate and tubuloglomerular feedback in A1AR-deficient mice with different genetic backgrounds
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چکیده
منابع مشابه
Tubuloglomerular feedback in ACE-deficient mice.
In these experiments, we used a strain of angiotensin converting enzyme (ACE) germline null mutant mice, generated by J. H. Krege and co-workers (J. H. Krege, S. W. M. John, L. L. Langenbach, J. B. Hodgin, J. R. Hagaman, E. S. Bachman, J. C. Jennette, D. A. O'Brien, and O. Smithies. Nature 375: 146-148, 1995), to examine the effect of chronic ACE deficiency on the magnitude of tubuloglomerular ...
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Studies in mice with null mutations of adenosine 1 receptor or ecto-5'-nucleotidase genes suggest a critical role of adenosine and its precursor 5'-AMP in tubulovascular signaling. To assess whether the source of juxtaglomerular nucleotides can be traced back to ATP dephosphorylation, experiments were performed in mice with a deficiency in NTPDase1/CD39, an ecto-ATPase catalyzing the formation ...
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“THE SUN WILL NOT RISE UNTIL after the first cup of coffee.” Who has not once required a mug of coffee to get going? Among the first things to do after draining the cup is to rebalance the body fluids. In fact, more volume is excreted than the amount of coffee consumed. Why is this so? Four members of our editorial team may have come a bit closer to answering this question (1, 6). The effects o...
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The circadian pattern of mean arterial pressure (MAP) and heart rate (HR) was measured in C57BL mice with carotid arterial catheters. Cardiovascular parameters were recorded continuously with a computerized monitoring system at a sampling rate of 100 Hz. The tethered animals were healthy, showing stabilized drinking and eating patterns within 2 days of surgery and little loss of body weight. An...
متن کاملMediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors.
Adenosine is a determinant of metabolic control of organ function increasing oxygen supply through the A2 class of adenosine receptors and reducing oxygen demand through A1 adenosine receptors (A1AR). In the kidney, activation of A1AR in afferent glomerular arterioles has been suggested to contribute to tubuloglomerular feedback (TGF), the vasoconstriction elicited by elevations in [NaCl] in th...
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ژورنال
عنوان ژورنال: Acta Physiologica
سال: 2014
ISSN: 1748-1708
DOI: 10.1111/apha.12377